Joel Sunshine M.D.

Loss of Effective Antigen Presentation in Melanoma and Treatment Failure

Loss of effective presentation of tumor antigens by melanoma may drive immunotherapy resistance. We will use multiplex immunofluorescence to map antigen presentation at single-cell resolution across whole slides, and correlate…

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Paul Haun M.D.

Biomarker Analysis of Transcriptome Signatures in Mycosis Fungoides Across Clinicopathologic Stages

Mycosis Fungoides (MF) is a rare disease that is difficult to diagnose and treat. Recent studies on the genomic signature of this disease have shown that MF is difficult to…

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Galen Foulke M.D.

Closing Practice Gaps in Dermatomyositis Malignancy Screening

Dermatomyositis is an autoimmune disease affecting skin and muscle, and 15%–20% of patients eventually develop cancer. Lack of evidence-based guidelines for malignancy screening represents a practice gap in dermatology and…

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Steven Chen M.D.

Investigation of Dermatologic Toxicity from Immune Checkpoint Blockade in Advanced Malignancies

Advanced malignancies are increasingly being treated with immune checkpoint inhibitors, which can lead to immune-related adverse events (irAEs), including those in the skin. This project will investigate key clinical, pathologic,…

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Tina Buthani M.D.

Evaluating the Impact of Sleep on Psoriasis and Associated Comorbidities

Sleep impairment is a risk factor for cardiovascular disease and metabolic disorders. Research shows that psoriasis patients are more likely to report sleep disturbance compared to people without psoriasis. This…

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Aayushi Uberoi Ph.D.

Skin Microbiome — Aryl Hydrocarbon Receptor Crosstalk at Skin Interface Regulates Barrier Function

A compromised skin barrier results in increased susceptibility to pathogens and chronic conditions (e.g., atopic dermatitis) that severely impact human appearance. The skin microbiome is a critical regulator of skin…

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Chen Wang M.D.

Identification of Disease-Driving T Cells and Antigens in Alopecia Areata

Alopecia areata (AA) is mediated by autoreactive T cells, but the antigen(s) targeted in this autoimmune response are unknown. This study seeks to identify disease-driving T cells in the skin…

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Christoph Ellebrecht M.D.

Development of Targeted Immunotherapy for, and Transcriptional Profiling of, γδ T Cell Diseases

Gamma-delta (gd) T-cells are involved in infection, inflammation, and cancer. We propose novel methods to develop T-cell–based immunotherapies to combat gd T-cell cancers, which may lead to lasting remission. We…

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Wesley Yu, MD

Preventing Metastasis of High-Risk Melanoma

In the U.S., more than 7,000 people die from melanoma annually. Up to one-third of these deaths are caused by early, localized melanomas (AJCC Stage 1–2) that metastasize despite appropriate…

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Identifying Molecular Determinants of Prognosis in Advanced Squamous Cell Carcinoma

Immunotherapy is a crucial treatment for advanced squamous cell cancers that cannot be cured by surgery alone. But it works only half of the time, and we do not know…

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