Characterizing the Microbiome in Postmenopausal Women with Vulvar Lichen Sclerosus
Vulvar lichen sclerosus is a chronic inflammatory condition that leads to scarring, obliteration of normal vulvar architecture, dyspareunia, and significant decrease in quality of life. Little is known about the refractory nature of this condition or which factors contribute to disease flares. Our study aims to determine whether the microbiome is altered in postmenopausal women with vulvar lichen sclerosus, and if this influences disease activity.
Melissa M. Mauskar, M.D.
- University of Texas Southwestern
- Women’s Health Research Grant
Exploring Gene Expression Patterns and Biomarkers of Disease Severity in Central Centrifugal Cicatricial Alopecia
Central centrifugal cicatricial alopecia (CCCA), which has been associated with uterine fibroids, is unlike other scarring alopecias because fibrosis rather…
Cell Signaling Changes Induced by Surgical Debulking May Improve Response to Smoothened Inhibitor Therapy
Smoothened (SMO) inhibitors, such as vismodegib, are effective treatments for locally advanced basal cell carcinomas (BCCs). However, recurrences are frequent…
Characterizing the Role of the Cutaneous Microbiota in Darier Disease
Darier disease is an inherited disorder of acantholytic dyskeratosis. Lesions are most prominent on seborrheic skin and are prone to…