Characterizing the Role of the Cutaneous Microbiota in Darier Disease
Darier disease is an inherited disorder of acantholytic dyskeratosis. Lesions are most prominent on seborrheic skin and are prone to secondary infections, which lead to disease flares and significant morbidity. We hypothesize that disruption of the cutaneous microbiota modulates phenotypic severity, and our project seeks to identify implicated pathogens and their interactions with the human exoproteome.
— Nan Ring, M.D.
- Yale University
- Research Grant
Exploring Gene Expression Patterns and Biomarkers of Disease Severity in Central Centrifugal Cicatricial Alopecia
Central centrifugal cicatricial alopecia (CCCA), which has been associated with uterine fibroids, is unlike other scarring alopecias because fibrosis rather…
Vulvar lichen sclerosus is a chronic inflammatory condition that leads to scarring, obliteration of normal vulvar architecture, dyspareunia, and significant…
Cell Signaling Changes Induced by Surgical Debulking May Improve Response to Smoothened Inhibitor Therapy
Smoothened (SMO) inhibitors, such as vismodegib, are effective treatments for locally advanced basal cell carcinomas (BCCs). However, recurrences are frequent…