Cell Signaling Changes Induced by Surgical Debulking May Improve Response to Smoothened Inhibitor Therapy
Smoothened (SMO) inhibitors, such as vismodegib, are effective treatments for locally advanced basal cell carcinomas (BCCs). However, recurrences are frequent upon treatment discontinuation. Our clinical observations suggest long-term remission for patients undergoing surgical debulking of exophytic BCCs prior to SMO inhibitor therapy. This study intends to correlate key oncogenic signaling pathways induced by surgical debulking with improved patient outcomes with SMO inhibitors.
Charlene Lam, M.D., M.P.H.
- The Pennsylvania State University
- Patient Directed Investigation Grant
Exploring Gene Expression Patterns and Biomarkers of Disease Severity in Central Centrifugal Cicatricial Alopecia
Central centrifugal cicatricial alopecia (CCCA), which has been associated with uterine fibroids, is unlike other scarring alopecias because fibrosis rather…
Vulvar lichen sclerosus is a chronic inflammatory condition that leads to scarring, obliteration of normal vulvar architecture, dyspareunia, and significant…
Darier disease is an inherited disorder of acantholytic dyskeratosis. Lesions are most prominent on seborrheic skin and are prone to…