Elucidating Genes Involved in the Pathogenesis of Lichen Planus and Lichenoid Dermatoses
We are investigating the pathogenesis of lichen planus (LP) and other lichenoid dermatoses using single-cell RNA sequencing and similar techniques on fresh lesional and nonlesional skin biopsies from patients. We will identify relevant cell types, proteins, and signaling pathways that may be responsible for driving disease, and confirm our findings in vitro with the ultimate goal of identifying novel therapeutic targets for these conditions.
— Anna E. Kersh, M.D., Ph.D.
- University of Pennsylvania
- Dermatologist Investigator Research Fellowship
Exploring Gene Expression Patterns and Biomarkers of Disease Severity in Central Centrifugal Cicatricial Alopecia
Central centrifugal cicatricial alopecia (CCCA), which has been associated with uterine fibroids, is unlike other scarring alopecias because fibrosis rather…
Vulvar lichen sclerosus is a chronic inflammatory condition that leads to scarring, obliteration of normal vulvar architecture, dyspareunia, and significant…
Cell Signaling Changes Induced by Surgical Debulking May Improve Response to Smoothened Inhibitor Therapy
Smoothened (SMO) inhibitors, such as vismodegib, are effective treatments for locally advanced basal cell carcinomas (BCCs). However, recurrences are frequent…