Exploring Gene Expression Patterns and Biomarkers of Disease Severity in Central Centrifugal Cicatricial Alopecia
Central centrifugal cicatricial alopecia (CCCA), which has been associated with uterine fibroids, is unlike other scarring alopecias because fibrosis rather than chronic inflammation is the ongoing dominant response. This study will characterize profibrotic gene expression patterns in various stages of CCCA. It will also evaluate for the presence of serum biomarkers to provide insight as to whether CCCA represents a systemic fibroproliferative process.
— Crystal U. Aguh, M.D.
- Johns Hopkins Medical Institutions
- Medical Dermatology Career Development Award
Vulvar lichen sclerosus is a chronic inflammatory condition that leads to scarring, obliteration of normal vulvar architecture, dyspareunia, and significant…
Cell Signaling Changes Induced by Surgical Debulking May Improve Response to Smoothened Inhibitor Therapy
Smoothened (SMO) inhibitors, such as vismodegib, are effective treatments for locally advanced basal cell carcinomas (BCCs). However, recurrences are frequent…
Darier disease is an inherited disorder of acantholytic dyskeratosis. Lesions are most prominent on seborrheic skin and are prone to…