Assessing the Functional Consequences of Mitochondrial Genomic Alterations in Cutaneous Aging
Mitochondria generate energy for cells. They contain their own genome, which supports their function. Photoaging is associated with alterations to this genome, but the effects of these changes on mitochondrial function and clinical photoaging remain unclear. In this work, I will use cells with mitochondrial genome changes and histochemical markers of mitochondrial dysfunction to understand the relationship between the mitochondrial genome, mitochondrial function, and photoaging.
— Amy Ruth Vandiver, M.D., Ph.D.
- University of California, Los Angeles
- Dermatologist Investigator Research Fellowship
Exploring Gene Expression Patterns and Biomarkers of Disease Severity in Central Centrifugal Cicatricial Alopecia
Central centrifugal cicatricial alopecia (CCCA), which has been associated with uterine fibroids, is unlike other scarring alopecias because fibrosis rather…
Vulvar lichen sclerosus is a chronic inflammatory condition that leads to scarring, obliteration of normal vulvar architecture, dyspareunia, and significant…
Cell Signaling Changes Induced by Surgical Debulking May Improve Response to Smoothened Inhibitor Therapy
Smoothened (SMO) inhibitors, such as vismodegib, are effective treatments for locally advanced basal cell carcinomas (BCCs). However, recurrences are frequent…