Modulation of Epidermal Plasticity by Keratin Intermediate Filaments
The epidermis faces a fundamental architectural challenge during tissue remodeling—balancing resistance to mechanical insult with plasticity. Without resistance, the epidermis cannot form a functional barrier. Without plasticity, growth and wound healing are impossible. We study how keratin intermediate filaments, key mediators of epidermal strength, also establish epidermal plasticity through dynamic interactions with the cellular force-generation and force-coordination machinery.
— Benjamin A. Nanes, M.D., Ph.D.
- UT Southwestern Medical Center
- Dermatologist Investigator Research Fellowship
Exploring Gene Expression Patterns and Biomarkers of Disease Severity in Central Centrifugal Cicatricial Alopecia
Central centrifugal cicatricial alopecia (CCCA), which has been associated with uterine fibroids, is unlike other scarring alopecias because fibrosis rather…
Vulvar lichen sclerosus is a chronic inflammatory condition that leads to scarring, obliteration of normal vulvar architecture, dyspareunia, and significant…
Cell Signaling Changes Induced by Surgical Debulking May Improve Response to Smoothened Inhibitor Therapy
Smoothened (SMO) inhibitors, such as vismodegib, are effective treatments for locally advanced basal cell carcinomas (BCCs). However, recurrences are frequent…