Modulation of Epidermal Plasticity by Keratin Intermediate Filaments


The epidermis faces a fundamental architectural challenge during tissue remodeling—balancing resistance to mechanical insult with plasticity. Without resistance, the epidermis cannot form a functional barrier. Without plasticity, growth and wound healing are impossible. We study how keratin intermediate filaments, key mediators of epidermal strength, also establish epidermal plasticity through dynamic interactions with the cellular force-generation and force-coordination machinery.

— Benjamin A. Nanes, M.D., Ph.D.

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