Elucidating the Role of Regulatory T Cells in Protecting Cutaneous Epithelial Stem Cell Niches

Jarish Coehn M.D.

This research will investigate the mechanisms that regulatory T cells (Tregs) use to protect epithelial stem cells (ESCs) from autoimmunity in a novel experimental model of scarring alopecia. Additionally, we will comprehensively define the immunophenotype and spatial relationship of Tregs and ESCs in healthy and diseased human skin. These lines of investigation have the potential to identify novel therapeutic strategies to treat alopecias and inflammatory dermatoses.

— Jarish Cohen, M.D., Ph.D.

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