Immunity and Lymphocyte Biology

Immunoediting in Cutaneous Squamous Carcinogenesis

Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer, with ~700,000 cases, ~3,000 deaths, and billions of dollars in annual treatment-associated costs in the U.S. Escape from immunosurveillance,…

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Distinguishing the Mechanisms of Tumoral Immune Response and Cutaneous Adverse Events

Checkpoint inhibitor (CPI) therapy has revolutionized cancer treatment, but generates immune-related adverse events (irAEs) that commonly include cutaneous effects. I hypothesize that the tumor response is mechanistically distinct from associated…

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Matthew Patrick Ph.D.

Identification of Shared Genetic and Modifiable Risk Factors for Psoriasis and Multiple Sclerosis

More than 40,000 people suffer from both psoriasis and multiple sclerosis (MS), which share a number of known genetic loci. IL-17 is significant in both diseases, and I hypothesize that…

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Jarish Coehn M.D.

Elucidating the Role of Regulatory T Cells in Protecting Cutaneous Epithelial Stem Cell Niches

This research will investigate the mechanisms that regulatory T cells (Tregs) use to protect epithelial stem cells (ESCs) from autoimmunity in a novel experimental model of scarring alopecia. Additionally, we…

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Paul Haun M.D.

Biomarker Analysis of Transcriptome Signatures in Mycosis Fungoides Across Clinicopathologic Stages

Mycosis Fungoides (MF) is a rare disease that is difficult to diagnose and treat. Recent studies on the genomic signature of this disease have shown that MF is difficult to…

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Chen Wang M.D.

Identification of Disease-Driving T Cells and Antigens in Alopecia Areata

Alopecia areata (AA) is mediated by autoreactive T cells, but the antigen(s) targeted in this autoimmune response are unknown. This study seeks to identify disease-driving T cells in the skin…

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Christoph Ellebrecht M.D.

Development of Targeted Immunotherapy for, and Transcriptional Profiling of, γδ T Cell Diseases

Gamma-delta (gd) T-cells are involved in infection, inflammation, and cancer. We propose novel methods to develop T-cell–based immunotherapies to combat gd T-cell cancers, which may lead to lasting remission. We…

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Contributions of Early Life Bacterial-Barrier-Immune Interactions in the Path to Atopy

Pediatric atopic dermatitis (AD) is a chronic, costly, and high-morbidity disease. The earliest events that precede disease onset and modulate severity in at-risk infants remain poorly defined. Using novel experimental…

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