Inflammation

Elucidating Genes Involved in the Pathogenesis of Lichen Planus and Lichenoid Dermatoses

We are investigating the pathogenesis of lichen planus (LP) and other lichenoid dermatoses using single-cell RNA sequencing and similar techniques on fresh lesional and nonlesional skin biopsies from patients. We…

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Matthew Patrick Ph.D.

Identification of Shared Genetic and Modifiable Risk Factors for Psoriasis and Multiple Sclerosis

More than 40,000 people suffer from both psoriasis and multiple sclerosis (MS), which share a number of known genetic loci. IL-17 is significant in both diseases, and I hypothesize that…

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Jarish Coehn M.D.

Elucidating the Role of Regulatory T Cells in Protecting Cutaneous Epithelial Stem Cell Niches

This research will investigate the mechanisms that regulatory T cells (Tregs) use to protect epithelial stem cells (ESCs) from autoimmunity in a novel experimental model of scarring alopecia. Additionally, we…

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Christoph Ellebrecht M.D.

Development of Targeted Immunotherapy for, and Transcriptional Profiling of, γδ T Cell Diseases

Gamma-delta (gd) T-cells are involved in infection, inflammation, and cancer. We propose novel methods to develop T-cell–based immunotherapies to combat gd T-cell cancers, which may lead to lasting remission. We…

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