Development of Targeted Immunotherapy for, and Transcriptional Profiling of, γδ T Cell Diseases
Gamma-delta (gd) T-cells are involved in infection, inflammation, and cancer. We propose novel methods to develop T-cell–based immunotherapies to combat gd T-cell cancers, which may lead to lasting remission. We will also perform comprehensive immune profiling of gd T-cells in COVID-19, in psoriasis, and in gd T-cell lymphoma, to better understand potential consequences of gd T-cell depletion and the pathways that drive gd-mediated diseases.
— Christoph T. Ellebrecht, M.D.
- University of Pennsylvania
- Physician Scientist Career Development Award
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