Contributions of Early Life Bacterial-Barrier-Immune Interactions in the Path to Atopy
Pediatric atopic dermatitis (AD) is a chronic, costly, and high-morbidity disease. The earliest events that precede disease onset and modulate severity in at-risk infants remain poorly defined. Using novel experimental approaches in human and murine models, we propose to define mechanisms whereby cutaneous exposure to bacteria in barrier-deficient neonates triggers development of AD. Our longer-term objective is to reduce global atopic burden by developing “smart” topical treatments for at-risk infants, which target the skin microbial community and/or the cytokines they elicit, thereby preventing early events in the atopic march.
— Tiffany A. Scharschmidt, M.D.
- University of California, San Francisco
- Sun Pharma Research Award
Exploring Gene Expression Patterns and Biomarkers of Disease Severity in Central Centrifugal Cicatricial Alopecia
Central centrifugal cicatricial alopecia (CCCA), which has been associated with uterine fibroids, is unlike other scarring alopecias because fibrosis rather…
Vulvar lichen sclerosus is a chronic inflammatory condition that leads to scarring, obliteration of normal vulvar architecture, dyspareunia, and significant…
Cell Signaling Changes Induced by Surgical Debulking May Improve Response to Smoothened Inhibitor Therapy
Smoothened (SMO) inhibitors, such as vismodegib, are effective treatments for locally advanced basal cell carcinomas (BCCs). However, recurrences are frequent…