Investigating Neuroimmune Interactions to Promote Scarless Skin Regeneration
Approximately 100 million new skin scars appear annually in the U.S. The many products marketed for scar prevention produce only modest results. We discovered that activation of the TRPA1 receptor on sensory neurons promotes scarless skin regeneration in mice. This current project aims to decipher molecular mechanisms controlling scar formation and skin regeneration in mammals, then identify new strategies to prevent scar formation in humans.
— Satish Sati, Ph.D.
- University of Pennsylvania
- Research Career Development Award
Exploring Gene Expression Patterns and Biomarkers of Disease Severity in Central Centrifugal Cicatricial Alopecia
Central centrifugal cicatricial alopecia (CCCA), which has been associated with uterine fibroids, is unlike other scarring alopecias because fibrosis rather…
Vulvar lichen sclerosus is a chronic inflammatory condition that leads to scarring, obliteration of normal vulvar architecture, dyspareunia, and significant…
Cell Signaling Changes Induced by Surgical Debulking May Improve Response to Smoothened Inhibitor Therapy
Smoothened (SMO) inhibitors, such as vismodegib, are effective treatments for locally advanced basal cell carcinomas (BCCs). However, recurrences are frequent…