Identification of Disease-Driving T Cells and Antigens in Alopecia Areata

Chen Wang M.D.

Alopecia areata (AA) is mediated by autoreactive T cells, but the antigen(s) targeted in this autoimmune response are unknown. This study seeks to identify disease-driving T cells in the skin of AA patients and characterize the antigens that they recognize. Successful completion of this project will provide mechanistic insights into disease pathogenesis, improve ability to track disease-relevant T cells, and enable development of antigen-specific therapies.

— Chen Wang, M.D., Ph.D.

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