Immunoediting in Cutaneous Squamous Carcinogenesis
Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer, with ~700,000 cases, ~3,000 deaths, and billions of dollars in annual treatment-associated costs in the U.S. Escape from immunosurveillance, a hallmark of cancer, is one of the defining steps in the progression from in situ disease (SCCIS) to cSCC. We will define the steps underlying this escape in SCCIS, with the goal of developing novel immunomodulatory chemoprevention therapeutics.
— Matthew L. Hedberg, M.D., Ph.D.
- University of Pennsylvania
- Research Grant
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