Epidermal Structure and Barrier Function
Characterizing the Role of the Cutaneous Microbiota in Darier Disease
Darier disease is an inherited disorder of acantholytic dyskeratosis. Lesions are most prominent on seborrheic skin and are prone to secondary infections, which lead to disease flares and significant morbidity….
Modulation of Epidermal Plasticity by Keratin Intermediate Filaments
The epidermis faces a fundamental architectural challenge during tissue remodeling—balancing resistance to mechanical insult with plasticity. Without resistance, the epidermis cannot form a functional barrier. Without plasticity, growth and wound…
Skin Microbiome — Aryl Hydrocarbon Receptor Crosstalk at Skin Interface Regulates Barrier Function
A compromised skin barrier results in increased susceptibility to pathogens and chronic conditions (e.g., atopic dermatitis) that severely impact human appearance. The skin microbiome is a critical regulator of skin…
Contributions of Early Life Bacterial-Barrier-Immune Interactions in the Path to Atopy
Pediatric atopic dermatitis (AD) is a chronic, costly, and high-morbidity disease. The earliest events that precede disease onset and modulate severity in at-risk infants remain poorly defined. Using novel experimental…