Skin Microbiome — Aryl Hydrocarbon Receptor Crosstalk at Skin Interface Regulates Barrier Function
A compromised skin barrier results in increased susceptibility to pathogens and chronic conditions (e.g., atopic dermatitis) that severely impact human appearance. The skin microbiome is a critical regulator of skin physiology. However, the chemical diversity of signals from skin microbes, and how keratinocytes decipher them, remain unexplored. Our goal is to understand how host–microbiota interactions regulate skin barrier integrity.
— Aayushi Uberoi, Ph.D.
- University of Pennsylvania
- Science of Human Appearance Career Development Award
Exploring Gene Expression Patterns and Biomarkers of Disease Severity in Central Centrifugal Cicatricial Alopecia
Central centrifugal cicatricial alopecia (CCCA), which has been associated with uterine fibroids, is unlike other scarring alopecias because fibrosis rather…
Vulvar lichen sclerosus is a chronic inflammatory condition that leads to scarring, obliteration of normal vulvar architecture, dyspareunia, and significant…
Cell Signaling Changes Induced by Surgical Debulking May Improve Response to Smoothened Inhibitor Therapy
Smoothened (SMO) inhibitors, such as vismodegib, are effective treatments for locally advanced basal cell carcinomas (BCCs). However, recurrences are frequent…