Characterizing the Genetics and Epigenetics of Linear Morphea
Morphea is an inflammatory skin disease that can be debilitating and disfiguring. Developing a better understanding of this disease is the first step toward better pharmacological treatments and preventive strategies. Scientists have only recently recognized the disease relevance of noncoding regions of the genome and developed the ability to study their effects. Our research aims to uncover the genetic causes of morphea by studying noncoding regions.
— Dawn Z. Eichenfield, MD, PhD
- University of California, San Diego
- Pediatric Dermatology Career Development Award
Related Articles
Exploring Gene Expression Patterns and Biomarkers of Disease Severity in Central Centrifugal Cicatricial Alopecia
Central centrifugal cicatricial alopecia (CCCA), which has been associated with uterine fibroids, is unlike other scarring alopecias because fibrosis rather…
Characterizing the Microbiome in Postmenopausal Women with Vulvar Lichen Sclerosus
Vulvar lichen sclerosus is a chronic inflammatory condition that leads to scarring, obliteration of normal vulvar architecture, dyspareunia, and significant…
Cell Signaling Changes Induced by Surgical Debulking May Improve Response to Smoothened Inhibitor Therapy
Smoothened (SMO) inhibitors, such as vismodegib, are effective treatments for locally advanced basal cell carcinomas (BCCs). However, recurrences are frequent…