Janet Celosia
Biomarker Analysis of Transcriptome Signatures in Mycosis Fungoides Across Clinicopathologic Stages
Mycosis Fungoides (MF) is a rare disease that is difficult to diagnose and treat. Recent studies on the genomic signature of this disease have shown that MF is difficult to…
Closing Practice Gaps in Dermatomyositis Malignancy Screening
Dermatomyositis is an autoimmune disease affecting skin and muscle, and 15%–20% of patients eventually develop cancer. Lack of evidence-based guidelines for malignancy screening represents a practice gap in dermatology and…
Investigation of Dermatologic Toxicity from Immune Checkpoint Blockade in Advanced Malignancies
Advanced malignancies are increasingly being treated with immune checkpoint inhibitors, which can lead to immune-related adverse events (irAEs), including those in the skin. This project will investigate key clinical, pathologic,…
Evaluating the Impact of Sleep on Psoriasis and Associated Comorbidities
Sleep impairment is a risk factor for cardiovascular disease and metabolic disorders. Research shows that psoriasis patients are more likely to report sleep disturbance compared to people without psoriasis. This…
Skin Microbiome — Aryl Hydrocarbon Receptor Crosstalk at Skin Interface Regulates Barrier Function
A compromised skin barrier results in increased susceptibility to pathogens and chronic conditions (e.g., atopic dermatitis) that severely impact human appearance. The skin microbiome is a critical regulator of skin…
Identification of Disease-Driving T Cells and Antigens in Alopecia Areata
Alopecia areata (AA) is mediated by autoreactive T cells, but the antigen(s) targeted in this autoimmune response are unknown. This study seeks to identify disease-driving T cells in the skin…
Development of Targeted Immunotherapy for, and Transcriptional Profiling of, γδ T Cell Diseases
Gamma-delta (gd) T-cells are involved in infection, inflammation, and cancer. We propose novel methods to develop T-cell–based immunotherapies to combat gd T-cell cancers, which may lead to lasting remission. We…
Preventing Metastasis of High-Risk Melanoma
In the U.S., more than 7,000 people die from melanoma annually. Up to one-third of these deaths are caused by early, localized melanomas (AJCC Stage 1–2) that metastasize despite appropriate…
Identifying Molecular Determinants of Prognosis in Advanced Squamous Cell Carcinoma
Immunotherapy is a crucial treatment for advanced squamous cell cancers that cannot be cured by surgery alone. But it works only half of the time, and we do not know…
Pain in Hidradenitis Suppurativa: The Role of Nerve Sensitization and Defining Pain Outcomes
Pain is the most important cause of disability and reduced quality of life (QoL) in hidradenitis suppurativa (HS). This proposal consists of (1) a prospective cross-sectional study using quantitative sensory…