Janet Celosia
Modulation of Epidermal Plasticity by Keratin Intermediate Filaments
The epidermis faces a fundamental architectural challenge during tissue remodeling—balancing resistance to mechanical insult with plasticity. Without resistance, the epidermis cannot form a functional barrier. Without plasticity, growth and wound…
Elucidating Genes Involved in the Pathogenesis of Lichen Planus and Lichenoid Dermatoses
We are investigating the pathogenesis of lichen planus (LP) and other lichenoid dermatoses using single-cell RNA sequencing and similar techniques on fresh lesional and nonlesional skin biopsies from patients. We…
Distinguishing the Mechanisms of Tumoral Immune Response and Cutaneous Adverse Events
Checkpoint inhibitor (CPI) therapy has revolutionized cancer treatment, but generates immune-related adverse events (irAEs) that commonly include cutaneous effects. I hypothesize that the tumor response is mechanistically distinct from associated…
Investigating Neuroimmune Interactions to Promote Scarless Skin Regeneration
Approximately 100 million new skin scars appear annually in the U.S. The many products marketed for scar prevention produce only modest results. We discovered that activation of the TRPA1 receptor…
Identification of Shared Genetic and Modifiable Risk Factors for Psoriasis and Multiple Sclerosis
More than 40,000 people suffer from both psoriasis and multiple sclerosis (MS), which share a number of known genetic loci. IL-17 is significant in both diseases, and I hypothesize that…
Optimizing Phototesting and Investigating Photobiology of Visible Light
Through improved means of investigating photoprotection efficacy extending into the visible waveband, the proposed studies should provide improved guidelines for testing sun protection agents that prevent sunburn in light-skinned individuals….
Elucidating the Role of Regulatory T Cells in Protecting Cutaneous Epithelial Stem Cell Niches
This research will investigate the mechanisms that regulatory T cells (Tregs) use to protect epithelial stem cells (ESCs) from autoimmunity in a novel experimental model of scarring alopecia. Additionally, we…
Characterizing the Genetics and Epigenetics of Linear Morphea
Morphea is an inflammatory skin disease that can be debilitating and disfiguring. Developing a better understanding of this disease is the first step toward better pharmacological treatments and preventive strategies….
Choice Help: Optimizing Outcomes by Supporting Encounters for Kids with Congenital Melanocytic Nevi
We need tools to support shared decision-making in pediatric dermatology as well as studies evaluating this process. Choice Help: Optimizing Outcomes by Supporting Encounters for kids with Congenital Melanocytic Nevi…
Loss of Effective Antigen Presentation in Melanoma and Treatment Failure
Loss of effective presentation of tumor antigens by melanoma may drive immunotherapy resistance. We will use multiplex immunofluorescence to map antigen presentation at single-cell resolution across whole slides, and correlate…