Inflammation
Elucidating Genes Involved in the Pathogenesis of Lichen Planus and Lichenoid Dermatoses
We are investigating the pathogenesis of lichen planus (LP) and other lichenoid dermatoses using single-cell RNA sequencing and similar techniques on fresh lesional and nonlesional skin biopsies from patients. We…
Identification of Shared Genetic and Modifiable Risk Factors for Psoriasis and Multiple Sclerosis
More than 40,000 people suffer from both psoriasis and multiple sclerosis (MS), which share a number of known genetic loci. IL-17 is significant in both diseases, and I hypothesize that…
Elucidating the Role of Regulatory T Cells in Protecting Cutaneous Epithelial Stem Cell Niches
This research will investigate the mechanisms that regulatory T cells (Tregs) use to protect epithelial stem cells (ESCs) from autoimmunity in a novel experimental model of scarring alopecia. Additionally, we…
Development of Targeted Immunotherapy for, and Transcriptional Profiling of, γδ T Cell Diseases
Gamma-delta (gd) T-cells are involved in infection, inflammation, and cancer. We propose novel methods to develop T-cell–based immunotherapies to combat gd T-cell cancers, which may lead to lasting remission. We…