Carcinogenesis and Cancer Genetics
Cell Signaling Changes Induced by Surgical Debulking May Improve Response to Smoothened Inhibitor Therapy
Smoothened (SMO) inhibitors, such as vismodegib, are effective treatments for locally advanced basal cell carcinomas (BCCs). However, recurrences are frequent upon treatment discontinuation. Our clinical observations suggest long-term remission for…
Immunoediting in Cutaneous Squamous Carcinogenesis
Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer, with ~700,000 cases, ~3,000 deaths, and billions of dollars in annual treatment-associated costs in the U.S. Escape from immunosurveillance,…
Biomarker Analysis of Transcriptome Signatures in Mycosis Fungoides Across Clinicopathologic Stages
Mycosis Fungoides (MF) is a rare disease that is difficult to diagnose and treat. Recent studies on the genomic signature of this disease have shown that MF is difficult to…
Identifying Molecular Determinants of Prognosis in Advanced Squamous Cell Carcinoma
Immunotherapy is a crucial treatment for advanced squamous cell cancers that cannot be cured by surgery alone. But it works only half of the time, and we do not know…